Truthfully, I've not been consistent with this product since I bought at dermatologist months ago. Due to cost, I only use once a day on my most severe forehead lines. I didn't think it was working, however, I stopped using for the last two weeks and can see the difference. Will now use as directed to test outcome for lip lines which are quite pronounced because I'm a lip purser. I do not use nueromodulators. FWIW, tip broke off the first month after a fall from the countertop -- no problem with dispensing without applicator.